Institutional Profile: Community for Open Antimicrobial Drug Discovery – Crowdsourcing New Antibiotics and Antifungals

Figures & data

Figure 1.  The Community for Open Antimicrobial Drug Discovery antimicrobial screening workflow.

ADME: Absorption, distribution, metabolism, excretion; CO-ADD: Community for Open Antimicrobial Drug Discovery; LCMS: Liquid chromatography mass spectrometry; MTA: Material transfer agreement; OM: Outer membrane; QC: Quality control; SAR: Structure–activity relationship; T&C: Terms and conditions.

Reproduced with permission from [5].

Figure 2.  The Community for Open Antimicrobial Drug Discovery engagement evolution.

CO-ADD: Community for Open Antimicrobial Drug Discovery.

Table 1. Community for Open Antimicrobial Drug Discovery hit rates as of November 2016.

Hit rate (confirmed hits with selectivity over mammalian cell cytotoxicity)	G+ve	G-ve	Fungi
CO-ADD academic hit rate	0.66%	0.21%	0.98%
Commercial hit rate	0.03%	0.008%	ND

CO-ADD: Community for Open Antimicrobial Drug Discovery; ND: Not determined.

Community for Open Antimicrobial Drug Discovery. www.co-add.org/

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