The Synergistic Effect of Hydroalcoholic Extracts of Origanum Vulgare, Hypericum Perforatum and Their Active Components Carvacrol and Hypericin Against Staphylococcus Aureus

Figures & data

Table 1. Results of fractional inhibitory concentration and disk diffusion of the groups.

Groups	Minimum inhibitory concentration	Fractional inhibitory concentration	Disk diffusion	Ref.
Origanum vulgare	625		15.66	[32]
Hypericum perforatum	625		12.66
Hypericin	78.12		36
Carvacrol	312.5		12.33
O. vulgare × H. perforatum		0.5	21
Hypericin × Carvacrol		0.49	51

Figure 1.  Synergistic effects of combination of hydroalcoholic Origanum vulgare and Hypericum perforatum extracts, and active ingredients carvacrol and hypericin by means of checkerboard test in a 96-well microplate.

Figure 2.  Synergistic effect of combination of hydroalcoholic Origanum vulgare and Hypericum perforatum extracts, and active ingredients carvacrol and hypericin by means of Fratini double-antibiotic synergistic test.

Bahmani M. Phytochemical profiles and antibacterial activities of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum, carvacrol and hypericin as a promising anti-Staphylococcus aureus. Ph.D thesis- project code “A-10-1379-1” and with the title “Evaluating the anti-bacterial and reconstructive effect of titanium dioxide nanoprojects synthesized with Origanum vulgare, Hypericum perforatum, carvacrol and hypericin loaded in alginate scaffolds in wounds infected with Staphylococcus aureus in diabetic rats” (2017). http://pajouhesh.lums.ac.ir/pass_req.php?sid=1&slc_lang=fa.

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