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International Journal of Pharmacokinetics Volume 3, 2018 - Issue 3
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Commentary

Extrapolation of Pharmacokinetic Interaction Data of Proton Pump Inhibitors Obtained in Healthy Subjects for Oral Targeted Therapies in Cancer Patients

Nuggehally R Srinivas1 Drug Metabolism & Pharmacokinetics, Zydus Research Centre, Sarkhej-Bavla NH 8A, Moraiya, Ahmedabad382210, Gujarat, India;2 Current affiliation: Innovation and Technology, Jubilant Life Sciences, D-12, Sector-59, Noida201301UP, IndiaCorrespondence[email protected]
Pages 93-97 | Received 03 Oct 2018, Accepted 26 Oct 2018, Published online: 30 Nov 2018

Figures & data

Figure 1. Flow chart showing the reported exposure (AUC) related pharmacokinetic drug–drug interaction between proton pump inhibitor versus oral targeted cancer drugs and excerpts from label claim instruction for the dosing of proton pump inhibitor in cancer patients.
Figure 1. Flow chart showing the reported exposure (AUC) related pharmacokinetic drug–drug interaction between proton pump inhibitor versus oral targeted cancer drugs and excerpts from label claim instruction for the dosing of proton pump inhibitor in cancer patients.

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