Central Composite Designed Solid Dispersion for Dissolution Enhancement of Fluvastatin Sodium By Kneading Technique

Abstract

Aim: This research is focused on enhancing aqueous solubility and dissolution of fluvastatin sodium (FSS) through solid dispersion (FSS-SD) production using polyethylene glycol 6000 and polyvinyl pyrollidone K-30 by kneading technique. Methodology & results: Central composite design explored the influence of polyethylene glycol 6000 and polyvinyl pyrollidone K-30 on T_50% and Q90. The aqueous saturation solubility of FSS (8.7 ± 1.12 μg/ml) was amplified 20-fold in FSS-SD (179 ± 4.16 μg/ml). Cumulative drug release from FSS and optimized FSS-SD were 27.49 and 87.4% within 90 min, respectively. Conclusion: FSS-SD production using kneading technique offers great prospective in maximizing FSS's solubility and dissolution.

Graphical abstract

Keywords:

• central composite design
• fluvastatin sodium
• hypercholesterolemia
• kneading technique
• polyethylene glycol 6000
• polyvinyl pyrollidone K-30

Author contributions

S Singh: Formulation development and optimization.

N Sharma: Physicochemical characterization, in vitro evaluation and stability study.

G Kaur: Formulation development and optimization.

Acknowledgments

The authors would like to thank Chitkara College of Pharmacy, Chitkara University, Punjab, India for supporting and encouraging this research work. The authors would like to acknowledge Stat-Ease, Inc for Design-Expert software (trial version 11.1.2.0, Stat-Ease Inc., MN, USA). The authors would also like to acknowledge CambridgeSoft for ChemDraw Ultra 12.0.2.1076 and Advanced Chemistry Development, Inc for ACD/ChemSketch (Freeware 2017.2.1). in the manuscript.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript