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Bedside to Bench Report

Grade 4 unclassified renal cell carcinoma with sarcomatoid component expressing S-100 protein. A case report with peculiar diagnostic and therapeutic implications

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Pages 1439-1443 | Received 11 Jun 2014, Accepted 16 Aug 2014, Published online: 16 Dec 2014

Figures & data

Figure 1. CT scan of the abdomen performed before the start of epirubicin plus dacarbazine treatment and 6 months later. The hepatic and adenopathic lesions regressed from 70.3 mm (A) to 36.8 mm (B) and from 58.9 × 45 mm (C) to 21.6 × 29.5 mm respectively (D).

Figure 1. CT scan of the abdomen performed before the start of epirubicin plus dacarbazine treatment and 6 months later. The hepatic and adenopathic lesions regressed from 70.3 mm (A) to 36.8 mm (B) and from 58.9 × 45 mm (C) to 21.6 × 29.5 mm respectively (D).

Figure 2. Microscopic features of the grade 4 unclassified renal cell carcinoma, with sarcomatoid component (URCCSC). (A) Patternless arrangement of tumor cells with pleomorphic and spindle cell morphology (H&E x10). (B) Focal immunopositivity for Keratins of neoplastic cells, showing epithelial differentiation. panCK (AE1, AE3,PCK26 clone) (H&E x 25). (C) Immunopositivity for S-100 of neoplastic cells. S-100 clone (H&E × 25).

Figure 2. Microscopic features of the grade 4 unclassified renal cell carcinoma, with sarcomatoid component (URCCSC). (A) Patternless arrangement of tumor cells with pleomorphic and spindle cell morphology (H&E x10). (B) Focal immunopositivity for Keratins of neoplastic cells, showing epithelial differentiation. panCK (AE1, AE3,PCK26 clone) (H&E x 25). (C) Immunopositivity for S-100 of neoplastic cells. S-100 clone (H&E × 25).

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