Figure 1. Relationship between senescence and the primary cilia. Frequency of primary cilia increases during senescence in human fibroblasts (middle) but not in human mammary epithelial cells (HMECs, right). During pancreatic tumorigenesis (left), primary cilia that are observed in normal ducts are lost in pancreatic intraepithelial neoplasias (PanIN) and pancreatic ductal adenocarcinomas (PDAC). PanIN lesions are enriched in senescent cells.
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