Figures & data
Figure 1. Models for eIF2B functions in protein synthesis initiation. (A) Original model depicting eIF2-GTP-Met-tRNAi recruitment to the ribosome and its release following GTP hydrolysis to eIF2-GDP upon mRNA AUG start codon recognition. Here eIF2B perfoms a single GEF step to reactivate eIF2. (B) Revised model for eIF2 recycling accounting for eIF5 GDI and eIF2B GDF functions. (C) New model showing the impact of eIF2α phosphorylation on eIF2B and eIF5. For further explanations, including step numbering, refer to the main text.
