Figure 1. The Yin and Yang of the yeast Mca1. The yeast Mca1 induces PCD under certain conditions (dark-half), probably by targeting unknown functional components crucial for cell survival (bright-island). It also plays a beneficial role in cell cycle control and by potentially removing nonfunctional misfolded proteins (dark-island), helps cells to maintain protein homeostasis to ensure cell growth and longevity together with chaperones and proteasomes (bright-half).
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