Figures & data
Figure 1. A schematic of the cellular processes affected by targeted protein degradation during Ras-induced senescence. Hyperactive ERK/MAPK (in red) leads to targeting of proteins to proteasomes for degradation (in blue). The authors suggest that PML nuclear bodies (PML-NBs) (in green) may serve as sites for nuclear protein degradation, and that increased turnover of nuclear and cytoplasmic targets contribute to the senescent phenotype.
