Figures & data
Figure 1. Proposed model: EGFRvIII CAR modified T-cell immunotherapy of GBM leads to immunogenic cell death and epitope spreading. EGFRvIII+ CAR targeted destruction of GBM [1] results in release of immunostimulatory cytokines by T cells and antigens and DAMPs by dying tumor cells [2]. APCs are recruited to the site of tumor destruction where they engulf dying tumor cells and become activated by DAMPs [3]. Mature DCs expressing multiple MHC-restricted tumor antigens traffic to the LN [4] where they prime naïve T cells recognizing novel tumor antigens [5]. Newly activated T cells traffic to tumor and destroy GBM based upon recognition of novel tumor antigens [6]. APC, antigen presenting cell; CAR, chimeric antigen receptor; DAMP, danger associated molecular pattern; DC, dendritic cell; EGFRvIII, epidermal growth factor receptor variant 3; GBM, glioblastoma multiforme; IFNɣ, interferon gamma; IL2, interleukin-2; LN, lymph node; TC, cytolytic T cell; TH, helper T cell; TNFα, tumor necrosis factor α.
![Figure 1. Proposed model: EGFRvIII CAR modified T-cell immunotherapy of GBM leads to immunogenic cell death and epitope spreading. EGFRvIII+ CAR targeted destruction of GBM [1] results in release of immunostimulatory cytokines by T cells and antigens and DAMPs by dying tumor cells [2]. APCs are recruited to the site of tumor destruction where they engulf dying tumor cells and become activated by DAMPs [3]. Mature DCs expressing multiple MHC-restricted tumor antigens traffic to the LN [4] where they prime naïve T cells recognizing novel tumor antigens [5]. Newly activated T cells traffic to tumor and destroy GBM based upon recognition of novel tumor antigens [6]. APC, antigen presenting cell; CAR, chimeric antigen receptor; DAMP, danger associated molecular pattern; DC, dendritic cell; EGFRvIII, epidermal growth factor receptor variant 3; GBM, glioblastoma multiforme; IFNɣ, interferon gamma; IL2, interleukin-2; LN, lymph node; TC, cytolytic T cell; TH, helper T cell; TNFα, tumor necrosis factor α.](/cms/asset/4ce244c1-941c-4afe-91ec-40465eaf5e12/koni_a_944059_f0001_oc.jpg)