Figures & data
Figure 1. Anti-RANKL antibody rescues melanoma-reactive T cells from thymic negative selection. (A) Aire in mTECs promotes melanoma antigen expression and negative selection of melanoma-reactive T effector (Teff) cells. As a result, the immune response against melanoma is limited. (B) Anti-RANKL antibody depletes Aire-expressing mTECs; as a result, melanoma-reactive Teff cells escape thymic negative selection. The increased pool of melanoma-reactive Teff cells contributes to a more effective anti-melanoma immune response.
