https://orcid.org/0000-0002-6428-428XView further author informationFigure 1. Anti-CTLA-4 monoclonal antibodies (mAbs) block CTLA-4 from inhibiting T cell activation. The resultant expansion and mobilization of activated T cells is reflected in the rapid turnover of the entire T cell repertoire in the periphery. In this representative example, each color represents a unique T cell clone as determined by next generation sequencing of rearranged TCRB genes and ranked by abundance.
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