Figures & data
Figure 1. A model of tumor heterogeneity and senescence evasion. Whereas both intrinsic and extrinsic mechanisms induce cellular senescence in the tumor tissue that constrains neoplastic cell growth and limits tumorigenesis, multiple events trigger senescence evasion in tumor cells, thus breaking down the barrier to cell proliferation and cancer progression.
![Figure 1. A model of tumor heterogeneity and senescence evasion. Whereas both intrinsic and extrinsic mechanisms induce cellular senescence in the tumor tissue that constrains neoplastic cell growth and limits tumorigenesis, multiple events trigger senescence evasion in tumor cells, thus breaking down the barrier to cell proliferation and cancer progression.](/cms/asset/ae8e11fe-22dc-4e4c-9358-aa2eec04351a/koni_a_988473_f0001_oc.jpg)