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Rare Diseases Volume 2, 2014 - Issue 1
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Addendum

The methyl binding domain containing protein MBD5 is a transcriptional regulator responsible for 2q23.1 deletion syndrome

Katherina WalzDr. John T Macdonald Foundation; Department of Human Genetics; University of Miami; FL, USA;John P. Hussman Institute for Human Genomics; University of Miami; FL, USA;Department of Medicine; Miller School of Medicine; University of Miami; FL, USA
&
Juan I YoungDr. John T Macdonald Foundation; Department of Human Genetics; University of Miami; FL, USA;John P. Hussman Institute for Human Genomics; University of Miami; FL, USACorrespondence[email protected]
Article: e967151 | Received 08 Sep 2014, Accepted 11 Sep 2014, Published online: 03 Nov 2014

Figures & data

Figure 1. Proliferating neural stem cells do not express MBD5. 2 month old Mbd5+/GT mice were treated with BrdU 24 h before brain collection and processed for X-gal (left panel) and BrdU immunolabeling (center panel). BrdU positive cells (arrows, merged right panel and magnified inset) in the subgranular zone do not show X gal staining, suggesting that newly generated cells in the brain do not express MBD5. GCL: granule cell layer.

Figure 1. Proliferating neural stem cells do not express MBD5. 2 month old Mbd5+/GT mice were treated with BrdU 24 h before brain collection and processed for X-gal (left panel) and BrdU immunolabeling (center panel). BrdU positive cells (arrows, merged right panel and magnified inset) in the subgranular zone do not show X gal staining, suggesting that newly generated cells in the brain do not express MBD5. GCL: granule cell layer.

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