Figures & data
Figure 1. Schematic working mechanism of a “corrector” and a “potentiator” for a pathogenic mutant form of ZIP13. (A) ZIP13 “corrector” inhibits the coordinated actions of cofactors including the identified molecules, VCP and HSP90, involved in the unfolding and transport of mutant ZIP13 to the proteasome. As a result, the “corrector” causes an effective amount of functional ZIP13 protein to accumulate. (B) ZIP13 “potentiator” alters the equilibrium toward the active form, improving the intracellular Zn homeostasis by increasing Zn influx.
