Figures & data
Figure 1. (A) Overlapping expression of Meis1 and Meis2 in relation to expression of HOX genes and members of the Pax4/6, Pax3/7 and Pax2/5/8 families in the mouse neural tube. Schematic views of mouse embryos at E11 are shown; the expression domains of the respective HOX genes is given without indicating any rhombomere-specific differences in gene expression levels. In the CNS anterior of the rhombomere 1–2 boundary, Meis1 and Meis2 are co-expressed with Pax3/7 in the mesencephalon, with Pax2/5/8 in the rostral mid-hindbrain boundary region and with Pax6 in the eye anlage. [di: diencephalic vesicle; mes: mesencephalic vesicle; met: metencephalic vesicle; o.s.: optic stalk; r: rhombomere; s.c.: spinal cord; tel: telencephalic vesicle.] (B) Schematic drawing of the major protein domains found in Meis-family members and different PAX proteins. Protein domains are not drawn to scale. MEIS family proteins contact members of the PBC-family of TALE-homeodomain proteins through MH-B, the C-terminal half of the bipartite MEIS-homology domain. [MH-A / MH-B: MEIS-homology domain A / B; TALE-HD: 3 amino acid loop extension homeodomain; paired: paired-domain; HD: homeodomain.]
![Figure 1. (A) Overlapping expression of Meis1 and Meis2 in relation to expression of HOX genes and members of the Pax4/6, Pax3/7 and Pax2/5/8 families in the mouse neural tube. Schematic views of mouse embryos at E11 are shown; the expression domains of the respective HOX genes is given without indicating any rhombomere-specific differences in gene expression levels. In the CNS anterior of the rhombomere 1–2 boundary, Meis1 and Meis2 are co-expressed with Pax3/7 in the mesencephalon, with Pax2/5/8 in the rostral mid-hindbrain boundary region and with Pax6 in the eye anlage. [di: diencephalic vesicle; mes: mesencephalic vesicle; met: metencephalic vesicle; o.s.: optic stalk; r: rhombomere; s.c.: spinal cord; tel: telencephalic vesicle.] (B) Schematic drawing of the major protein domains found in Meis-family members and different PAX proteins. Protein domains are not drawn to scale. MEIS family proteins contact members of the PBC-family of TALE-homeodomain proteins through MH-B, the C-terminal half of the bipartite MEIS-homology domain. [MH-A / MH-B: MEIS-homology domain A / B; TALE-HD: 3 amino acid loop extension homeodomain; paired: paired-domain; HD: homeodomain.]](/cms/asset/efb0d656-329e-424b-b7ee-ec40b265fc4c/kngs_a_976014_f0001_c.gif)