Figures & data
Figure 1. Potential synaptic mechanisms underlying the orexin-evoked increase in activity of sympathetic premotor neurons for BAT in rostral raphe pallidus (rRPa). (A) Orexin could bind to presynaptic orexin receptors to augment the ongoing release of glutamate onto BAT sympathetic premotor neurons (gray sphere). (B) Orexin could act at postsynaptic orexin receptors on BAT sympathetic premotor neurons to increase their excitability, thereby augmenting their discharge evoked by active glutamatergic inputs. (C) Orexin binding to postsynaptic orexin receptors could stimulate synthesis of endocannabinoid, which would increase the activity of the BAT sympathetic premotor neurons in rRPa by acting retrogradely to inhibit a tonic GABA release from presynaptic terminals.
