Figure 1. At the sarco/endoplasmic reticulum (SR/ER), the BCL2-CISD2 complex associates with the ITPR Ca2+ channel. In this setting, BCL2-CISD2 may negatively modulate the BECN1 phagophore-initiating complex and regulate ER Ca2+ homeostasis. It remains to be determined if ensuing changes in Ca2+ levels at the ER, cytosol and mitochondria signal changes in the activity of the BECN1 complex, autophagy status and mitochondrial morphology.
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