Figures & data
Figure 1. Simplified scheme of nonselective vs. selective autophagy, and how they might be affected in cancer cells by oncogenic pathways and stressors in the microenvironment such as the hypoxia triggered by anti-angiogenic therapy. Shown are regulators of nonselective vs. selective autophagy in tumor cells. Hypoxia, as caused by anti-angiogenic therapy, influences both nonselective and selective autophagy, with mechanisms more clearly identified for the former. Abbreviations used: ROS, reactive oxygen species; HIF1A, hypoxia-inducible factor-1α; AMPK, AMP-activated protein kinase; and EGLN1/PHD2, prolyl hydroxylase domain-containing protein 2.
