Figures & data
Figure 1. NUPR1 is involved against metabolic stress-associated cell death. Pancreatic ductal adenocarcinoma is hypovascularized as a consequence of its high stroma content. Thus, pancreatic cancer cells become nutrient starved and subjected to long periods of hypoxia. Glucose starvation and hypoxia mediate, on the one hand, inhibition of DNA repair- and cell cycle-associated gene expression, resulting in an autophagy-associated cell death, and, on the other hand, the induction of NUPR1 expression to maintain DNA repair- and cell cycle-associated gene expression and therefore promote cell survival by inhibiting autophagy-associated cell death. However, cannabinoids induce NUPR1-mediated autophagy-dependent cell death by controlling a different set of genes.
