Figure 1. TAS1R1-TAS1R3 directly detects amino acids leading to the activation of MTORC1 and inhibition of autophagy. This receptor activates MTORC1, in part, through the activation of phospholipase C (PLC), the increase in intracellular calcium, and the activation of MAPK1-MAPK3. TAS1R1-TAS1R3 is required for the amino acid-induced MTOR localization to the lysosome, a necessary step in MTORC1 activation.
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