Figures & data
Figure 1. An unconventional function of autophagic structures in the regulation of MAPK phosphorylation. (A) We propose that phagophores and autophagosomes serve as cellular signaling platforms that allow the RAF1-MAP2K-MAPK signaling cascade to dock on the surface to facilitate EGF-induced MAPK phosphorylation. (B) Acute exposure to trehalose that increases LC3-II content and autophagy without interfering with the MTOR pathway increases MAPK phosphorylation. (C) Increasing LC3-II availability by silencing ATG4B, which decreases LC3-II recycling, associates with increased MAPK phosphorylation.
