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Autophagic Punctum

Atg1 kinase organizes autophagosome formation by phosphorylating Atg9

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Pages 1338-1340 | Received 25 Mar 2014, Accepted 22 Apr 2014, Published online: 28 Apr 2014

Figures & data

Figure 1. Atg1-dependent Atg9 phosphorylation regulates autophagy. Atg1 phosphorylates Atg9 on 6 consensus sites upon PAS recruitment (i). This allows the efficient recruitment of Atg18 and possibly Atg14 to the PAS (ii) and Atg9 binding to Atg18, which is required for Atg8 recruitment and phagophore elongation (iii) in autophagy and the Cvt pathway.

Figure 1. Atg1-dependent Atg9 phosphorylation regulates autophagy. Atg1 phosphorylates Atg9 on 6 consensus sites upon PAS recruitment (i). This allows the efficient recruitment of Atg18 and possibly Atg14 to the PAS (ii) and Atg9 binding to Atg18, which is required for Atg8 recruitment and phagophore elongation (iii) in autophagy and the Cvt pathway.