Figures & data
Figure 1. Speculative cartoon representation of segregated Atg8-functions. (A) Atg8 recognizes an AIM in Atg12, thereby recruiting the Atg12–Atg5-Atg16 complex to membranes. Together with Atg12–Atg5 conjugates Atg8–PE forms oligomeric particles comprising 2 to 4 Atg8–PE-Atg12–Atg5 complexes. Atg16 crosslinks these particles by forming antiparallel oligomers. (B) The scaffold associates at the convex face of autophagosomes. Atg8–PE also localizes to the concave face, where it tethers cargo such as mitochondria to the phagophore by interacting with cargo-specific receptors, for example Atg32.
