Figures & data
Figure 1. Atg37 regulates the assembly of the pexophagic RPC. Atg37 is an integral PMP, which, similar to the pexophagy receptor, Atg30, binds Pex3 in the peroxisomal membrane. Atg37 is also an acyl-CoA binding protein that binds either palmitoyl-CoA or Atg30. Atg30 recruits Atg37 to the pexophagic RPC where Atg37 facilitates the engagement of the scaffold protein Atg11. To bind both Atg11 and the phagophore protein Atg8, Atg30 has to be phosphorylated (P) at the corresponding binding sites. Acyl-CoA (AC) might regulate the Atg30-Atg37 interaction and as a consequence affect the recruitment of Atg11 to the pexophagic RPC.
