Figures & data
Figure 1. Proposed model for the regulation of tumor growth by KIAA1524/CIP2A and autophagy. KIAA1524/CIP2A inhibits PP2A-mediated dephosphorylation of MTORC1 substrates RPS6KB1 and EIF4EBP1 thereby enhancing the MTORC1 signaling pathway. Together with previously reported effects of KIAA1524/CIP2A on stabilization of MYC, activation of E2F1 and AKT as well as inhibition of DAPK1, KIAA1524/CIP2A enhances tumor cell growth by stimulating protein synthesis, cell metabolism and proliferation as well as by inhibiting apoptosis. Conversely, MTORC1 inhibition leads to autophagic degradation of KIAA1524/CIP2A and reversal of its tumor-promoting activities.
