Figures & data
Figure 1. Model of Parkin-mediated mitochondrial clearance. Upon loss of mitochondrial membrane potential (Δψm) Parkin translocates to the mitochondria in a PINK1-dependent manner. After translocation, Parkin ubiquitinates outer mitochondrial membrane proteins. In addition, Parkin recruits Ambra1, which induces perimitochondrial nucleation of new phagophores through its effect on class III PtdIns3K. The expanding phagophore then associates with LC3, which tethers the phagophore to the ubiquitinated mitochondria via p62 or other receptor proteins. Ub, ubiquitin.
