Figure 1. Regulation of autophagy by the NAC1-HMGB1 pathway. Under stress conditions, NAC1 increases the expression, cytosolic translocation, and release of HMGB1; in the cytoplasm, HMGB1 disrupts the binding of Beclin 1 with Bcl-2. Association of HMGB1 with Beclin 1 promotes autophagy activity.
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