Figures & data
Figure 1 Structures of the lantibiotics Nisin A, Pep5, Lacticin 481, Nukacin ISK-1 with charged amino acids highlighted (positively charged residues in blue, negatively charged residues in maroon, Ala-S-Ala [lanthionine] as light grey, Abu-S-Ala [β-methyl lanthionine] in dark grey colored, other amino acid residues in yellow color). Asterisks correspond to residues altered in the charge mutants referred to in the text.
![Figure 1 Structures of the lantibiotics Nisin A, Pep5, Lacticin 481, Nukacin ISK-1 with charged amino acids highlighted (positively charged residues in blue, negatively charged residues in maroon, Ala-S-Ala [lanthionine] as light grey, Abu-S-Ala [β-methyl lanthionine] in dark grey colored, other amino acid residues in yellow color). Asterisks correspond to residues altered in the charge mutants referred to in the text.](/cms/asset/3c370249-4ee3-4ff2-9d29-cd190a83db2e/kbie_a_10912353_f0001.gif)
Figure 2 Structures of Ltnα like peptides with charged amino acids highlighted (positively charged residues in blue, negatively charged residues in maroon, Ala-S-Ala [lanthionine] as light grey, Abu-S-Ala [β-methyl lanthionine] in dark grey colored, D-alanine in brown, other amino acid residues in yellow color). Asterisks correspond to residues altered in the charge mutants referred to in the text.
![Figure 2 Structures of Ltnα like peptides with charged amino acids highlighted (positively charged residues in blue, negatively charged residues in maroon, Ala-S-Ala [lanthionine] as light grey, Abu-S-Ala [β-methyl lanthionine] in dark grey colored, D-alanine in brown, other amino acid residues in yellow color). Asterisks correspond to residues altered in the charge mutants referred to in the text.](/cms/asset/68391317-9e61-4f4e-b04d-60c071a8f1ad/kbie_a_10912353_f0002.gif)
Figure 3 Ltnβ like peptides with charged amino acids highlighted (positively charged residues in blue, negatively charged residues in maroon, Ala-S-Ala [lanthionine] as light grey, Abu-S-Ala [β-methyl lanthionine] in dark grey colored, D-alanine in brown, other amino acid residues in yellow color). Asterisks correspond to residues altered in the charge mutants referred to in the text.
![Figure 3 Ltnβ like peptides with charged amino acids highlighted (positively charged residues in blue, negatively charged residues in maroon, Ala-S-Ala [lanthionine] as light grey, Abu-S-Ala [β-methyl lanthionine] in dark grey colored, D-alanine in brown, other amino acid residues in yellow color). Asterisks correspond to residues altered in the charge mutants referred to in the text.](/cms/asset/68d85ef9-6dc5-4f23-87bf-53ffb122faa1/kbie_a_10912353_f0003.gif)
Table 1 BioactivityTable Footnote* of lacticin 3147 charged mutant against different indicator strains
Table 2 MIC activityTable Footnote* of lacticin 3147 and N15K variant against selected targets