Figures & data
Figure 1. In the bottom part is depicted a schematic plot of the bead velocity as a function of the cortactin concentration. At low concentrations, cortactin enhances the release of WASP-VCA molecules from the newly-formed branches, which induce an increase in the bead velocity. At high concentrations cortactin has an inhibitory effect due to its high affinity to F-actin, leading to its attachment to the filaments and prevents the binding of WASP-VCA-Arp2/3 complex and branch formation.
