Figure 1. Schematic illustration to strategies of optimizing cationic polymer-mediated RNAi: (1) regulating the interaction between polyplexes and the serum in the biological environment to modulate the particles size for efficient internalization and low cytotoxicity; (2) improving the interaction between polyplexes and the cell membrane to increase targeting endocytosis; (3) facilitating the endo-lysosomal escape of polyplexes by stimuli-responsive modification.
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