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Research Paper

Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer

, , , , , , , , , , & show all
Pages 50-57 | Received 16 Sep 2010, Accepted 06 Oct 2010, Published online: 01 Jan 2011

Figures & data

Figure 1 Representative examples of immunohistochemically stained sections positive for EGFR (A and B), pAkt (C and D) and pERK (E and F) in tumor specimens ([A, C and E], x20 original magnification; [B, D and F] x40 original magnification). Scale bars represent 100 µm.

Figure 1 Representative examples of immunohistochemically stained sections positive for EGFR (A and B), pAkt (C and D) and pERK (E and F) in tumor specimens ([A, C and E], x20 original magnification; [B, D and F] x40 original magnification). Scale bars represent 100 µm.

Figure 2 Survival curves with Kaplan-Meier method of 102 ovarian cancer patients. Progression-free survival and overall survival of patients according to FIGO stage (A), EGFR gene mutation status (B), EGFR expression status (C) and pAkt expression status (D). p values were calculated using the log-rank test.

Figure 2 Survival curves with Kaplan-Meier method of 102 ovarian cancer patients. Progression-free survival and overall survival of patients according to FIGO stage (A), EGFR gene mutation status (B), EGFR expression status (C) and pAkt expression status (D). p values were calculated using the log-rank test.

Table 1 Patient characteristics

Table 2 Type of EGFR gene mutations

Table 3 Correlation with clinicopathological features and molecular markers

Table 4 Multivariate analysis for survival rates