Figures & data
Figure 1 Schematic representation showing barriers to siRNA-mediated cancer therapy. Stability problems associated with naked siRNA delivery can be prevented by chemical modifications and encapsulation. Improved delivery of siRNA has been achieved by preparing nanocrystals (e.g., Graphene oxide), nanocarriers and microcarriers. Cellular uptake of the encapsulated siRNA is dependent on hydrophobicity and endocytosis. Biodegradable and biocompatible Hydrogel preparations are used for the sustained release of therapeutic siRNAs.
