The heat shock proteins as targets for radiosensitization and chemosensitization in cancer

Figures & data

Figure 1 Proposed mechanisms of action for HSP inhibitors in radiosensitization and chemosensitization.

Table 1 Major heat shock proteins involved in radiosensitization and chemosensitization

Heat shock protein	Sub-family	ATP dependence	Effect	Inhibitors of HSP function in radiosensitization and chemosensitization	References
Hsp90	Large	ATP dependent	Stabilizes cell growth signaling molecules through chaperone activity Antiapoptotic Promotes endothelial cell proliferation and mobility	Small molecule-17-AAG, 17-DMAG, geldanamycin, radicicol	3, 4, 7, 11, 18–22, 55, 56
Hsp70	Large	ATP dependent	Stabilizes cell growth signaling molecules through chaperone activity Antiapoptotic Antinecrotic Promotes endothelial cell proliferation and mobility	None in clinical use, though several small molecule inhibitors have been identified (review in Powers et al.)	3, 4, 7, 911, 24, 25, 27, 28, 30, 55, 56
Hsp60	Large	ATP dependent	Proapoptotic Antiapoptotic	None identified to date	7, 29, 30, 32, 33
Hsp27	Small	ATP independent	Stabilizes cell growth signaling molecules through chaperone activity Antiapoptotic Antinecrotic Promotes endothelial cell proliferation and mobility Antioxidant Actin stabilization Proteasome activation	Small molecule- Zerumbone Nucleic acid-Antisense oligonucleotide, siRNA, others in development Protein aptamer	4, 7, 9, 14, 22, 36, 37, 42, 44–53, 55, 56

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