Figures & data
Table 1. The ONCODEATH Consortium
Figure 1. The central objective of this proposal was the investigation of the role of defective apoptotic pathways in human colon tumor cells in order to exploit them in developing novel treatment protocols. A multilateral course of action was planned, which involved genetic, cell biology and biochemical approaches. The Work plan was broken down in activities that partially or totally depended on each other and further dissected to work-packages, which corresponded to the major subdivisions of the program. The structure of the project reflected the complimentarity of the approaches and of the expertise of the participants. Thus, each participant has been contributing to several work-packages. The integration of the single contributions has been fundamental to successfully execute the tasks. A list of developed and/or characterized reagents is presented in .
Table 2. Reagents generated and/or characterized by the ONCODEATH consortium
Table 3. Summary of evaluated combinatorial treatments in pre-clinical studies in 2D, 3D cell cultures and animal models
Figure 2. Intrinsic and extrinsic apoptotic pathways regulated by TRAIL. Key molecules are shown (by K. Drosopoulos and E. Oikonomou, NHRF, Athens).
