Serum calcium, tumor size, and hormone receptor status in women with untreated breast cancer

Figures & data

Table 1. Descriptive characteristics of newly diagnosed breast patients aged 40- to 79-y-old

Variables corrected serum calcium levels (mg/dL)
	n = 555(%)	Mean (SD)	Range	P value
Age (years)				0.001
40–49	79 (14)	9.33 (0.42)	8.40–10.50
50–64	226 (41)	9.49 (0.45)	7.40–11.20
65–79	250 (45)	9.54 (0.48)	7.90–11.40
Body mass index (kg/m2)				0.58
Normal (< 25)	107 (19)	9.49 (0.46)	8.40–11.10
Overweight (25 - < 30)	195 (35)	9.46 (0.47)	7.40–11.40
Obese (> = 30)	253 (46)	9.52 (0.46)	8.20–11.20
Estrogen receptor				0.08
Negative	82 (16)	9.56 (0.43)	8.60–11.10
Positive	443 (84)	9.47 (0.47)	7.40–11.40
Progesterone receptor				0.64
Negative	133 (25)	9.50 (0.46)	8.40–11.20
Positive	394 (75)	9.48 (0.47)	7.40–11.40
Receptors combination				0.08
ER-/PR-	79 (14)	9.57 (0.43)	8.60–11.10
ER+/PR+	391 (70)	9.48 (0.47)	7.40–11.40
Tumor grades				0.14
Well-differentiated	94 (18)	9.42 (0.40)	8.40–10.80
Moderately differentiated	240 (45)	9.51 (0.45)	7.90–10.80
Poorly differentiated	196 (37)	9.53 (0.49)	8.40–11.40
Tumor size				0.04
≤ 2cm	399 (77)	9.46 (0.46)	7.40–11.10
> 2 cm	116 (23)	9.57 (0.46)	8.50–11.40
Stage at diagnosis				0.84
0	128 (24)	9.53 (0.50)	7.40–11.20
I	243 (45)	9.43 (0.46)	7.90–10.80
II*	121 (22)	9.56 (0.46)	8.50–11.40
III	39 (7)	9.47 (0.41)	8.80–10.40
IV	11 (2)	9.44 (0.43)	8.90–10.2

* Stage II vs. Stage I; p = 0.035

Table 2. Corrected serum calcium level determinants and coefficients for multiple linear regression analysis

Coefficients	(SE)	P value
Age at diagnosis	0.0053 (0.002)	0.0085
Body mass index (kg/m2)	0.0049 (0.003)	0.1031
Estrogen receptor negative	0.1540 (0.084)	0.0663
Progesterone receptor negative	-0.1145 (0.069)	0.1022
Poorly-differentiated tumors	0.0299 (0.050)	0.5505
Tumor size > 2 cm	0.1166 (0.051)	0.0233
Late stage (IIIB, IIIC, IV)	0.0077 (0.105)	0.9414

SE: standard error