A comparative study of cell cycle mediator protein expression patterns in anaplastic and papillary thyroid carcinoma

Figures & data

Table 1. Anaplastic vs. papillary thyroid carcinoma: Immunohistochemical results

	ATC	PTC	Unadjusted P value	Bonferonni adjusted p value
Cyclin D1	15/20 (75%)	19/21 (90.5%)	0.37	1.00
Cyclin E	7/20 (35%)	2/21 (9.5%)	0.11	1.00
Aurora A	18/20 (90%)	21/21 (100%)	0.45	1.00
Thyroglobulin	4/19 (21.1%)	20/21 (95.2%)	< 0.0001	< 0.0001
p53	10/19 (52.6%)	0/21 (0%)	0.0005	0.0055
p16	6/19 (31.6%)	14/21 (66.7%)	0.06	0.66
p21	6/20 (30%)	14/21 (66.7%)	0.04	0.44
Ki-67	17/20 (85%)	3/21 (14.3%)	< 0.0001	0.0004
OGF	19/20 (95%)	21/21 (100%)	0.98	1.00
OGFR	17/19 (89.5%)	13/21 (61.9%)	0.10	1.00
EGFR	16/16 (100%)	20/21 (95.2%)	0.02	0.22

N (%) with mean positive staining (mean score ≥ 25%)

Figure 1. Hematoxylin and eosin stained sections of anaplastic (A) and papillary (B) thyroid carcinoma. ATC (C) showed a significant increase in staining for p53 as compared with PTC (D). Both ATC (E) and PTC (F) showed diffuse positive staining for cyclin D1. Although not statistically significant, ATC (G) was less likely to be p21 positive than PTC (H). Original magnification 200 x for all images.