Figures & data
Figure 1 Nature of cancer cells.
Figure 1 Coordinated regulation of autophagy and apoptosis by azacitidine. (A) Azacitidine (AZA) causes the induction of autophagy and apoptosis in acute myeloid leukemia (AML) cells, presumably through demethylation of DNA and perhaps through off-target effects. Inhibition of autophagy stimulates cell killing by AZA (B) Chronic exposure of the cells to AZA leads to a permanent state of elevated autophagy without cell death that is maintained upon transient withdrawal of AZA. Moreover, AZA-resistant cells fail to die in response to the readdition of AZA to the cells, even when autophagy is inhibited.
