Figures & data
Figure 1. Diverse mechanisms of cilia length control in vertebrates. (A) FGF and Notch signaling influence cilia length, motility and cilia-directed fluid flow via the ciliogenic factor fox1j. (B) cAMP signaling and intracellular calcium levels modulate cilia length through changes in anterograde IFT speed. Ciliary bending by fluid flow shortens cilia via cAMP inhibition. (C) The ARP2/3 complex negatively regulates the elongation of cilia by promoting actin filament polymerization. (D) The phospholipase PLA2G3 inhibits ciliary elongation by influencing endocytic vesicular trafficking. (E) TORC1-dependent translation of ciliary precursors regulates cilia length, motility and cilia-directed flow.
