Figures & data
Figure 1. Schematic model depicting the role of IKK inhibition in regulating FOXO3a and NFκB nuclear translocation. In T-ALL, when Notch is mutated and constitutive active, IKK is constant active, which phosphorylates IκB and elicits NFκB nuclear translocation and promote tumorigenesis. The active IKK also sequesters FOXO3a in the cytoplasm. Inhibition of IKK by BMS-345541 triggers FOXO3a nuclear translocation and induces cell cycle arrest and apoptosis.
