Figures & data
Figure 1. (A) A schematic representation of our hypothesis showing conformational changes to the topology of a chromosome in prostate epithelial cells induced by ERG resulting in the formation of an activating transcription hub involving 3 pro-invasion genes. The dotted blue line represents the basement membrane and basal cell layer of a prostate gland. (B) Shown are the reconstruction 3D models of the organization of chromosome 6 in benign prostate epithelial cells (RWPE1) in the presence (right) or absence (left) of ERG.
