Figures & data
Figure 1. Structures of TLS, EWS, TAF15, CHOP and TLS-CHOP. Domains of TLS, CHOP and TLS-CHOP are depicted, including the activation domain (AD), RGG boxes that contribute to RNA binding (RGG), RNA-binding domain (RBD), Cys2-Cys2 zinc finger (ZF), DNA-binding domain (DBD) and leucine zipper domain (LZ). The location of sarcoma breakpoints (arrowheads) and ALS-related missense mutations in TLS (stars) are also depicted.
