p53-Aurora A mitotic feedback loop regulates cell cycle progression and genomic stability

Figures & data

Figure 1. p53-Aurora A mitotic feedback loop regulating p53 and Aurora A function. Distinct pathways modulating p53 and Aurora A activity at the transcriptional (Trx) or post-transcriptional (Post-Trx) level are depicted by thick lines, numbered one to seven, with P indicating phosphorylation (PO₄) and up and down red arrows reflecting upregulated and downregulated protein or RNA amounts, respectively.