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Cell Cycle Volume 11, 2012 - Issue 22
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Editorials: Cell Cycle Features

Attenuation of the ubiquitin conjugate DNA damage signal by the proteasomal DUB POH1

Joanna R. Morris School of Cancer Sciences; College Medical and Dental Sciences; University of Birmingham; Birmingham, UKCorrespondence[email protected]
Pages 4103-4104 | Published online: 17 Oct 2012

Figures & data

Figure 1. Model of POH1-mediated restriction of 53BP1 through K63- poly-Ub cleavage. RNF8/168 modify histones with K63-linked Ub. The combined activity of the removal of chromatin binding proteins (JMJD2A/B, not shown) and K63-poly-Ub generation promotes the accumulation of 53BP1 to the mark. POH1 activity counters this by promotes JMJD2A residence in chromatin (not shown) and by hydrolysing K63-poly-Ub.Citation1 The BRCA1-A complex is tethered by SUMO interactionCitation7 and does not spread.

Figure 1. Model of POH1-mediated restriction of 53BP1 through K63- poly-Ub cleavage. RNF8/168 modify histones with K63-linked Ub. The combined activity of the removal of chromatin binding proteins (JMJD2A/B, not shown) and K63-poly-Ub generation promotes the accumulation of 53BP1 to the mark. POH1 activity counters this by promotes JMJD2A residence in chromatin (not shown) and by hydrolysing K63-poly-Ub.Citation1 The BRCA1-A complex is tethered by SUMO interactionCitation7 and does not spread.

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