New epigenetic pathway for stemness maintenance mediated by the histone methyltransferase Ezh1

Figures & data

Figure 1. In the hematopoietic system, where stem cell activation is a transitory state that requires a combination of self-renewal coupled with the prevention of differentiation and senescence, Ezh1 is needed to maintain primitive hematopoietic cells by protecting them from differentiation and senescence in slow cycling through its PRC2-associated Polycomb function.