Figures & data
Figure 1. Wip1 inactivation and degradation lead to truncated DDR in mitosis. Wip1 phosphatase terminates the DDR. Here, the concept of yin-yang is used to represent the harmony of phosphorylation (p = Yin-dark) and ubiquitination (Ub = Yang-white) events in the coordination of the fully activated DDR during G1, S, and G2. Only the fully activated DDR can execute DNA repair. The domination of Yin (P) in the DDR results from the truncated and inactive DDR during mitosis (M), which can identify, but not repair, DNA damage. The inactivation and degradation of Wip1 enables the existence of truncated DDR (Yin) in mitosis. Once the cell exits mitosis, Wip1 expression gradually increases.
