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Cell Cycle Volume 12, 2013 - Issue 15
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Editorials: Cell Cycle Features

Chromatin dynamics

Flipping the switch on a chromatin remodeling machine

Shinya Watanabe Program in Molecular Medicine; University of Massachusetts Medical School; Worcester, MA USA
&
Craig L Peterson Program in Molecular Medicine; University of Massachusetts Medical School; Worcester, MA USACorrespondence[email protected]
Pages 2337-2338 | Received 03 Jun 2013, Accepted 03 Jun 2013, Published online: 11 Jul 2013

Figures & data

Figure 1. Regulatory interaction between SWR-C and H3K56Ac mediates multiple cycles of histone-exchange. While SWR-C only catalyzes H2A.Z deposition on unacetylated nucleosomes, SWR-C can catalyze both deposition and eviction of H2A.Z on H3-K56Ac nucleosomes, leading to high turnover of H2A.Z.

Figure 1. Regulatory interaction between SWR-C and H3K56Ac mediates multiple cycles of histone-exchange. While SWR-C only catalyzes H2A.Z deposition on unacetylated nucleosomes, SWR-C can catalyze both deposition and eviction of H2A.Z on H3-K56Ac nucleosomes, leading to high turnover of H2A.Z.

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