Figures & data
Figure 1. Top: pathways of EGFR internalization at low and high EGF concentration. Middle: schematic representation of EGFR ubiquitination, phosphorylation, and endocytic routes as a function of ligand concentration. Bottom: cooperativity mechanism responsible for the EGFR–Ub threshold. Three phosphotyrosines (pY) are critical for the cooperative recruitment of Cbl to active EGFR: pY1045 binds directly to Cbl, pY1068/pY1086 bind indirectly to Cbl:Grb2 complex.
![Figure 1. Top: pathways of EGFR internalization at low and high EGF concentration. Middle: schematic representation of EGFR ubiquitination, phosphorylation, and endocytic routes as a function of ligand concentration. Bottom: cooperativity mechanism responsible for the EGFR–Ub threshold. Three phosphotyrosines (pY) are critical for the cooperative recruitment of Cbl to active EGFR: pY1045 binds directly to Cbl, pY1068/pY1086 bind indirectly to Cbl:Grb2 complex.](/cms/asset/96f07589-6924-4c5d-b556-b8fa3d5bc37c/kccy_a_10927855_f0001.gif)