Figures & data
Figure 1. miR-34a mediates p53 pro-differentiation effects with subsequent SIRT6 silencing in keratinocytes. Top: In normal epidermis, p53 activation promotes differentiation in cells of the proliferative compartment through increased expression of miR-34a, which inhibits SIRT6 expression. In SCCs, loss of p53 and miR-34a result in SIRT6 protein accumulation and impaired differentiation. Bottom: Mechanistically, upon differentiating signals, p53 activates transcriptionally miR-34a expression, which, in turn, inhibits SIRT6 expression via direct binding to its 3′UTR.
