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Cell Cycle Volume 13, 2014 - Issue 9
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Editorials: Cell Cycle Features

Post-translational modifications in embryonic cell cycle

Siem Van der Laan Genome Surveillance and Stability Laboratory; Department Molecular Bases of Human Diseases; CNRS-UPR1142; Institute of Human Genetics; Montpellier, France
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Domenico Maiorano Genome Surveillance and Stability Laboratory; Department Molecular Bases of Human Diseases; CNRS-UPR1142; Institute of Human Genetics; Montpellier, FranceCorrespondence[email protected]
Pages 1364-1365 | Received 30 Jan 2014, Accepted 05 Feb 2014, Published online: 03 Apr 2014

Figures & data

Figure 1. Schematic representation of developmental transitions mediated by protein post-translational modifications (PTMs). In Drosophila, PTMS are implicated in pre- to post-midblastula transition (MBT). The enzyme(s) responsible for Drosophila Cdc25 (twine) downregulation at MBT are unknown (question mark). In mouse embryonic stem cells (ESCs) PMTs change Cdc25A stability through Dub3 downregulation upon differentiation. Graphs represent cell cycle profiles.

Figure 1. Schematic representation of developmental transitions mediated by protein post-translational modifications (PTMs). In Drosophila, PTMS are implicated in pre- to post-midblastula transition (MBT). The enzyme(s) responsible for Drosophila Cdc25 (twine) downregulation at MBT are unknown (question mark). In mouse embryonic stem cells (ESCs) PMTs change Cdc25A stability through Dub3 downregulation upon differentiation. Graphs represent cell cycle profiles.

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